Publications

  1. Mukhtar, A.; Zaheer, M.; Saeed, M.; Voelter, W. Synthesis of lignin model compound containing a beta-O-4 linkage, Z. Naturforsch. B 2017, 72, 119-24.
  2. Nilaweera, T.; Saeed, M.; Kohen, A. Targeting de novo biosynthesis of thymidylate for the development of positron emission tomography (PET) probe for cancer imaging. Biochemistry 2015, 54, 1287-93.
  3. Saeed, M.; Tewson, TJ.; Erdahl, CE.; Kohen, A., A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells. Nuc. Med. Biol. 2012, 39, 697-70 (Selected for news highlights in Global Medical Discovery)
  4. Cavalieri, E.; Saeed, M.; Zahid, M.; Cassada, D.; Snow, D.; Miljkovic, M.; Rogan, E., Mechanism of DNA depurination by carcinogens in relation to cancer initiation. IUMBM Life 2012, 64, 169-79.
  5. Kamel, M.; Shouman, S.; El-Merzebany, M.; Kilic, G.; Veenstra, T.; Saeed, M.; Wagih, M.; Diaz-Arrastia, C.; Patel, D.; Salama, S., Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells. J. Cancer 2012, 3, 310-21.
  6. Zahid, M.; Saeed, M.; Yang, L.; Beseler, C.; Rogan, E.; Cavalieri, E., Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson’s disease. IUBMB Life 2011, 63, (12), 1087-93.
  7. Hinrichs, B.; Zahid, M.; Saeed, M.; Au, M. F.; Cavalieri, E. L.; Rogan, E. G., Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol. J. Steroid Biochem. Mol. Biol. 2011, 127, (3-5), 276-8 1.
  8. Saeed, M.; Sheff, D.; Kohen, A., A novel positron emission tomography tracer distinguishes normal from cancerous cells. J. Biol Chem 2011, 286, (39), 33872-8.
  9. Williams-Brown, M. Y.; Salih, S. M.; Xu, X.; Veenstra, T. D.; Saeed, M.; Theiler, S. K.; Diaz-Arrastia, C. R.; Salama, S. A., The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk. J. Steroid Biochem. Mol. Biol. 2011, 126, (3-5), 78-86.
  10. Zahid, M.; Saeed, M.; Beseler, C.; Rogan, E. G.; Cavalieri, E. L., Resveratrol and N – acetylcysteine block the cancer-initiating step in MCF-10F cells. Free Radic Biol. Med. 2011, 50, (1), 78-85.
  11. Zahid, M.; Saeed, M.; Ali, M. F.; Rogan, E. G.; Cavalieri, E. L., N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells. Free Radic Biol. Med. 2010, 49, (3), 392-400.
  12. Zahid, M.; Saeed, M.; Rogan, E. G.; Cavalieri, E. L., Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease. Free Radic. Biol. Med. 2010, 48, (2), 318-24.
  13. Singh, S.; Zahid, M.; Saeed, M.; Gaikwad, N. W.; Meza, J. L.; Cavalieri, E. L.; Rogan, E. G.; Chakravarti, D., NAD(P)H:quinone oxidoreductase 1 Argi 39Trp and Pro 1 875er polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. J. Steroid Biochem Mol Biol. 2009, 117, (1-3), 56-66.
  14. Salama, S. A.; Kamel, M. W.; Botting, S.; Salih, S. M.; Borahay, M. A.; Hamed, A. A.; Kilic, G. S.; Saeed, M.; Williams, M. Y.; Diaz-Arrastia, C. R., Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells. PLoS One 2009, 4, (10), e7356.
  15. Saeed, M.; Rogan, E.; Cavalieri, E., Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: the defining link to natural estrogens. Int. J. Cancer 2009, 124, (6), 1276-84.
  16. Saeed, M.; Higginbotham, S.; Gaikwad, N.; Chakravarti, D.; Rogan, E.; Cavalieri, E., Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation. Free Radic. Biol. Med. 2009, 47, (7), 1075-81.
  17. Zahid, M.; Gaikwad, N. W.; Ali, M. F.; Lu, F.; Saeed, M.; Yang, L.; Rogan, E. G.; Cavalieri, E. L., Prevention of estrogen-DNA adduct formation in MCF- 1 OF cells by resveratrol. Free Radic. Biol. Med. 2008, 45, (2), 136-45.
  18. Lu, F.; Zahid, M.; Wang, C.; Saeed, M.; Cavalieri, E. L.; Rogan, E. G., Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-1OF cells. Cancer Prev. Res. (Philadelphia) 2008, 1, (2), 135-45.
  19. Zahid, M.; Saeed, M.; Lu, F.; Gaikwad, N.; Rogan, E.; Cavalieri, E., Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation. Free Radic. Biol. Med. 2007, 43, (11), 1534-40.
  20. Saeed, M.; Rogan, E.; Fernandez, S. V.; Sheriff, F.; Russo, J.; Cavalieri, E., Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol. Int. J. Cancer 2007, 120, (8), 1821-4.
  21. Saeed, M.; Higginbotham, S.; Rogan, E.; Cavalieri, E., Formation of depurinating N3adenine and N7guanine adducts after reaction of 1,2-naphthoquinone or enzyme-activated 1,2-dihydroxynaphthalene with DNA. Implications for the mechanism of tumor initiation by naphthalene. Chem.–Biol. Interact. 2007, 165, (3), 175-88.
  22. Lu, F.; Zahid, M.; Saeed, M.; Cavalieri, E. L.; Rogan, E. G., Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition. J. Steroid Biochem. Mol. Biol. 2007, 105, (1-5), 150-8.
  23. Zahid, M.; Kohli, E.; Saeed, M.; Rogan, E.; Cavalieri, E., The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity. Chem. Res. Toxicol. 2006, 19, (1), 164-72.
  24. Saeed, M.; Zahid, M.; Rogan, E.; Cavalieri, E., Synthesis of the catechols of natural and synthetic estrogens by using 2-iodoxybenzoic acid (IBX) as the oxidizing agent. Steroids 2005, 70, (3), 173-8.
  25. Saeed, M.; Zahid, M.; Gunselman, S. J.; Rogan, E.; Cavalieri, E., Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3′,4′-quinone. Implications for mutagenic activity. Steroids 2005, 70, (1), 29-3 5.
  26. Saeed, M.; Gunselman, S. J.; Higginbotham, S.; Rogan, E.; Cavalieri, E., Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3′,4′-quinone or enzyme-activated 3′-hydroxyhexestrol. Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens. Steroids 2005, 70, (1), 37-45.
  27. Markushin, Y.; Kapke, P.; Saeed, M.; Zhang, H.; Dawoud, A.; Rogan, E. G.; Cavalieri, E. L.; Jankowiak, R., Development of monoclonal antibodies to 4-hydroxyestrogen-2-N-acetylcysteine conjugates: immunoaffinity and spectroscopic studies. Chem. Res. Toxicol. 2005, 18, (10), 1520-7.
  28. Saeed, M.; Rogan, E.; Cavalieri, E., Novel spiro-quinone formation from 3 ‘-hydroxydiethylstilbestrol after oxidation with silver oxide. Tetrahedron Letters 2005, 46, (26), 4449-4451.
  29. Abdel-Jalil, R. J.; Voelter, W.; Saeed, M., A novel method for the synthesis of 4(3H)-quinazolinones. Tetrahedron Lett. 2004, 45, (17), 3475-3476.
  30. Dolashka-Angelova, P.; Schwarz, H.; Dolashki, A.; Stevanovic, S.; Fecker, M.; Saeed, M.; Voelter, W., Oligomeric stability of Rapana venosa hemocyanin (RvH) and its structural subunits. Biochim. Biophys. Acta 2003, 1646, (1-2), 77-85.
  31. Saeed, M.; Abbas, M.; Abdel-Jalil, R. J.; Zahid, M.; Voelter, W., A convenient method for the synthesis of cyclic trithiocarbonates on carbohydrate scaffolds. Tetrahedron Lett. 2003, 44, (2), 3 15-3 17.
  32. Saeed, M.; Abbas, M.; Heinrich, A.; Voelter, W., An efficient approach to the synthesis of tn­substituted iminothiazolidenes and their effects on the human neuroblastoma cell line. Tetrahedron Lett. 2003, 44, (32), 6107-6110.
  33. Zahid, M.; Saeed, M.; Asim, M.; Ishrud, 0.; Wu, S. H.; Abmad, V. U.; Pan, Y. J., New glycosides from Salvia moorcroftiana (Lamiaceae). Helv. Chim. Acta 2003, 86, (6), 2021-2027.
  34. Khan, K. M.; Saify, Z. S.; Shah, S. T.; Abmed, M.; Saeed, M.; Hayat, S.; Abbas, M.; Voelter, W., Syntheses, antibacterial, cytotoxic and antifungal effects of new 3-carboxy-l-phenacylpynidinium salts. Arzneimittel forschung/Drug Res. 2002, 52, (4), 286-93.
  35. Cavalieni, E. L.; Li, K. M.; Balu, N.; Saeed, M.; Devanesan, P.; Higginbotham, S.; Zhao, J.; Gross, M. L.; Rogan, E. G., Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases. Carcinogenesis 2002, 23, (6), 1071-7.
  36. Khan, K. M.; Saify, Z. S.; Shah, S. T. A.; Ahmed, M.; Saeed, M.; Hayat, S.; Abbas, M.; Voelter, W., Syntheses, antibacterial, cytotoxic and antifungal effects of new 3-carboxy- 1-phenacylpyridinium salts. Arzneimittel-Forschung-Drug Res. 2002, 52, (4), 286-293.
  37. Abdel-Jalil, R. J.; Saeed, M.; Voelter, W., An expeditious approach to fri-substituted chiral thiazolines. Tetrahedron Lett. 2001, 42, (13), 243 5-2437.
  38. Saeed, M.; Abbas, M.; Khan, K. M.; Voelter, W., Total synthesis of S-(+)-argentilactone. Zeitschrfl Fur Naturforschung Section B-a Journal of Chemical Sciences 2001, 56, (3), 325-328.
  39. Saeed, M.; Abdel-Jalil, R. J.; Voelter, W.; El-Abadelah, M. M., An expeditious synthesis of optically pure 1 ,4,5,6-tetrahydro-as-triazines, fused to the carbohydrate skeleton. Chem. Lett. 2001, (7), 660-661.
  40. Saeed, M.; Ilg, T.; Schick, M.; Abbas, M.; Voelter, W., Total synthesis and anti-leishmanial activity of R-(-)-argentilactone. Tetrahedron Lett. 2001, 42, (42), 7401-7403.
  41. Khan, K. M.; Saify, Z. S.; Khan, Z. A.; Ahmed, M.; Saeed, M.; Schick, M.; Kohlbau, H. J.; Voelter, W., Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives. Arzneimittel forschung/Drug Res. 2000, 50, (10), 9 15-24.
  42. Abdel-Jalil, R. J.; Saeed, M.; Heeg, P.; Voelter, W., Synthesis and properties of selected 4-substituted anhydro sugars. Zeitschrfl Fur Naturforschung Section B-a Journal of Chemical Sciences 2000, 55, (7), 66 1-666.
  43. Khan, K. M.; Saify, Z. S.; Zeeshan; Khan, A.; Ahmed, M.; Saeed, M.; Abdel-Jalil, R. J.; Grubler, G.; Voelter, W., Syntheses of selected quatemaly phenacylbromopyridinium compounds and their biological evaluation. Zeitschrfl Fur Naturforschung Section B-a Journal of Chemical Sciences 1999, 54, (9), 1210-1218.
  44. Saify, Z. S.; Khan, K. M.; Haider, S. M.; Zeeshan; Shah, S. T. A.; Saeed, M.; Shekhani, M. S.; Voelter, W., Syntheses and evaluation of the analgesic activity of some 4-acetyl-4-phenylpiperidine and 4-hydroxy-4-phenylpiperidine derivatives. Zeitschrzfi Fur Naturforschung Section B-a Journal of Chemical Sciences 1999, 54, (10), 1327-1336.