About Us

The Bioorganic & Medicinal Chemistry (BMC) group is committed to advancing science at the interface of chemistry and biology. Our research focuses on organic synthesis, computational chemistry, molecular modeling, and biological evaluation to discover new therapeutic agents and smart drug delivery platforms. We explore areas such as anticancer and antiviral drug discovery, endocrine‑resistant breast cancer, peptide‑based nanomaterials, and sustainable catalytic technologies. Through interdisciplinary training and international collaborations, we aim to bridge fundamental chemistry with translational biomedical research, empowering the next generation of scientists.

Publications
 


*2026

1- Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 3-(benzo[d][1,3]dioxol-5-yl)-2-(pyridin-3-yl)thiazolidin-4-one Authors: Summara Kousar, Raed Al‑Qawasmeh, Monther Khanfar, Muhammad Saeed
European Journal of Chemistry
DOI: https://doi.org/10.5155/eurjchem.17.2.99-108.2778

2- Selective Plastic Photo Upcycling to Acetic Acid via Coupled Oxidation and CO₂ Reduction Over an S‑Scheme g‑C₃N₄/Fe₂O₃ Heterojunction Authors: Zunaira Muhammad, Muhammad Saeed, Senem Çitoğlu, Hatice Duran, Salman Noshear Arshad ChemPlusChem DOI: https://doi.org/10.1002/cplu.202500710

*2025

3- Thermoselective Synthesis of Drug Intermediates Using Sulphonic Acid Functionalized Heterogeneous Catalysts
Authors: Shahzad Rasheed, Summara Kousar, Muhammad Saeed, Qandeel Almas
Presented at the 2025 AIChE Annual Meeting (Conference abstract – DOI not assigned)

4- Probing Solid‑Supported Alkali and Alkaline Earth Metal Salts‑Based Catalysts in the Multicomponent Synthesis of Acridine‑1,8‑diones: Box–Behnken and Density Functional Theory (DFT) Study Authors: Nisar Ali, Sehrish Sarfaraz, Hina Asif, Minahil Abbas, Mariya Al‑Rashida, Muhammad Saeed, Sobia Rana, Khurshid Ayub, Abdul Hameed ChemistrySelect
DOI:https://doi.org/10.1002/slct.202504095

5- Probing Solid‑Supported Alkali and Alkaline Earth Metal Salts‑Based Catalysts in the Multicomponent Synthesis of Acridine‑1,8‑diones: Box–Behnken and Density Functional Theory (DFT) Study
Authors: Nisar Ali, Sehrish Sarfaraz, Hina Asif, Minahil Abbas, Mariya Al‑Rashida, Muhammad Saeed, Sobia Rana, Khurshid Ayub, Abdul Hameed ChemistrySelect
DOI:https://doi.org/10.1002/slct.202504095
*2024

6- Fabrication of CuWO₄@MIL‑101 (Fe) nanocomposite for efficient OER and photodegradation of methylene blue
Authors: Mariam Khan, Muhammad Mahboob Ahmed, Muhammad Nadeem Akhtar, Muhammad Sajid, Nagina Naveed Riaz, Muhammad Asif, Muhammad Kashif, Bushra Shabbir, Khalil Ahmad, Muhammad Saeed, Maryam Shafiq, Tayyaba Shabir
Heliyon, December 15, 2024

7- Optimization study and application of Box–Behnken model for probing eggshell supported transition metals based catalysts to synthesize hydrazone & dihydropyrimidinones Authors: Rabia Perveen, Fiza Latif, Minahil Abbas, Khurshid Ayub, Sehrish Sarfaraz, Muhammad Saeed, Sobia Rana, Mariya Al‑Rashida, Muhammad Asif Nawaz, Abdul Hameed Scientific Reports

8- Synthesis of 3‑methyl‑N‑((4′‑(3‑methylbenzamido)‑[1,1′‑biphenyl]‑4‑yl)carbamothioyl)benzamide, X‑ray structural analysis, DFT‑guided investigation, Hirshfeld analysis and docking to jack bean urease Authors: Faiza Younas, Aamer Saeed, Tuncer Hökelek, Carola Schulzke, Sarwat Tahira, Benedict J. Elvers, Muhammad Saeed
Journal of Molecular Structure
DOI:https://doi.org/10.1016/j.molstruc.2024.138399

9- Iron‑catalysed C–H ortho‑arylation of edaravone, a promising monoamine oxidase‑B inhibitor Authors: Soneela Asghar, Mattia Manzotti, Alexander Atkins, Sanita Tailor, Hazel A. Sparkes, Muhammad Saeed, Robin B. Bedford Tetrahedron, April 18, 2024 DOI: https://doi.org/10.1016/j.tet.2024.133983

10- Facile synthesis of substituted 2‑aroylbenzo[b]thiophen‑3‑ols to form novel triazole hybrids using click chemistry Authors: Asma Mukhtar, Arif Hussain, Faiza Younas, Sammer Yousuf, Muhammad Saeed RSC Advances, March 28, 2024
DOI: https://doi.org/10.1039/d4ra01146e
*2023

11- Part‑II: An update of Schiff bases synthesis and applications in medicinal chemistry – a patent review (2016–2023) Authors: Hafiza Amna Younus, Faiza Saleem, Abdul Hameed, Mariya Al‑Rashida, Raed A. Al‑Qawasmeh, Mohamed El‑Naggar, Sobia Rana, Muhammad Saeed, Khalid Mohammed Khan Expert Opinion on Therapeutic Patents, December 2, 2023 DOI:https://doi.org/10.1080/13543776.2023.2297729

12- Repurposing of investigational cancer drugs: Early phase discovery of dengue virus NS2B/NS3 protease inhibitors Authors: Hafiza N. Saleem, Summara Kousar, Ammar Hassan Jiskani, Iqra Sohail, Amir Faisal, Muhammad Saeed Archiv der Pharmazie, August 15, 2023 DOI: https://doi.org/10.1002/ardp.202300292

13- The photocatalytic and antibacterial potential of highly efficient S‑scheme binary S‑gC₃N₄@Co‑zinc ferrite nanocomposite Authors: Syeda Saba Hassan, Mohsin Javed, Muhammad Nadeem Akhtar, Muhammad Azam Qamar, Naveed Ahmed, Muhammad Saeed, Komal Aroosh, Saira Khan, Samia Asif
Optical Materials, August 1, 2023
DOI:https://doi.org/10.1016/j.optmat.2023.114046

14- Plasma‑based ozonolysis of lignin waste materials for the production of value‑added chemicals Authors: Rabia Muazzam, Ainy Hafeez, Maliha Uroos, Muhammad Saeed, Fahad Rehman, Nawshad Muhammad Biomass Conversion and Biorefinery, May 13, 2023 DOI: https://doi.org/10.1007/s13399-021-01707-3

15- Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: synthesis, biological evaluation and in silico study
Authors: Hafiza Amna Younus, Muhammad Saeed, Abid Mahmood, Muhammad Siraj Khan Jadoon, Abdul Hameed, Asnuzilawati Asari, Habsah Mohamad, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Mariya Al‑Rashida
Bioorganic Chemistry, May 1, 2023

Publications – 2022

16- Endophytic bacteria of Fagonia indica Burm. f revealed to harbour rich secondary antibacterial metabolites
Authors: Lubna Rahman, Asma Mukhtar, Sajjad Ahmad, Lutfur Rahman, Muhammad Ali, Muhammad Saeed, Zabta Khan Shinwari
PLOS ONE, December 15, 2022

17- Synthesis, X‑Ray crystallography and HF/DFT analysis of N‑(diethylcarbamothioyl) furan‑2‑carboxamide, analyzed by experimental and theoretical methods
Authors: Aamer Saeed, Saba Ashraf, Ghulam Shabir, Tuncer Hökelek, Ulrich Flörke, Asma Mukhtar, Muhammad Saeed
Journal of Molecular Structure, November 15, 2022

18- Novel carboxylic acid‑capped silver nanoparticles as antimicrobial and colorimetric sensing agents
Authors: Muhammad Imran Irfan, Fareeha Amjad, Azhar Abbas, Muhammad Fayyaz Ur Rehman, Fariha Kanwal, Muhammad Saeed, Sami Ullah, Changrui Lu
Molecules, May 24, 2022
DOI:https://doi.org/10.3390/molecules27113363

19- Synthetic flavonoids as potential antiviral agents against SARS‑CoV‑2 main protease
Authors: Farwa Batool, Ehsan Ullah Mughal, Komal Zia, Amina Sadiq, Nafeesa Naeem, Asif Javid, Zaheer Ul‑Haq, Muhammad Saeed
Journal of Biomolecular Structure and Dynamics, May 24, 2022
DOI: https://doi.org/10.1080/07391102.2022.2045678

20- Postharvest shelf life enhancement of peach fruit treated with glucose oxidase immobilized on ZnO nanoparticles
Authors: Razia Batool, Syed Akif Raza Kazmi, Shazia Khurshid, Muhammad Saeed, Sikandar Ali, Ahmad Adnan, Faizah Altaf, Aminah Hameed, Farwa Batool, Noor Fatima
Food Chemistry, January 1, 2022
DOI:https://doi.org/10.1016/j.foodchem.2021.130591
Publications – 2021

21- Minocycline Derived Silver Nanoparticles for Assessment of Their Antidiabetic Potential against Alloxan induced Diabetic Mice
Authors: Syed Akif Raza Kazmi, Muhammad Zahid Qureshi, Saleh S. Alhewairini, Shaukat Ali, Shazia Khurshid, Muhammad Saeed, Shumaila Mumtaz, Tafail Akbar Mughal
Pharmaceutics, June 1, 2021
DOI:https://doi.org/10.3390/pharmaceutics13101678


22- Catalytic C–O bond cleavage in a β‑O‑4 lignin model through intermolecular hydrogen transfer
Authors: Muhammad Ahsan Usman, Maham Naeem, Muhammad Saeed, Muhammad Zaheer
Inorganica Chimica Acta, June 1, 2021
DOI: 10.1016/j.ica.2021.120305

23- Facile Synthesis and In Vitro Activity of N‑Substituted 1,2‑Benzisothiazol‑3(2H)‑ones against Dengue Virus NS2BNS3 Protease
Authors: Farwa Batool, Muhammad Saeed, Hafiza Nosheen Saleem, Luisa Kirschner, Jochen Bodem
Pathogens, April 12, 2021
DOI: 10.3390/pathogens10040464

24- Organizational flexibility and project portfolio performance: the roles of innovation, absorptive capacity and environmental dynamism
Authors: Muhammad Aamir Saeed, Yuanyuan Jiao, Muhammad Mohsin Zahid, Humaira Tabassum, Shazia Nauman
International Journal of Managing Projects in Business, April 6, 2021
DOI: 10.1108/IJMPB-02-2020-0058

25- Schiff‑based metal complexes of lamotrigine: design, synthesis, characterization, and biological evaluation
Authors: Saima Najm, Humaira Naureen, Kishwar Sultana, Fareeha Anwar, Muhammad Mubbashir Khan, Humaira Nadeem, Muhammad Saeed
ACS Omega, March 15, 2021Publications – 2020
DOI: 10.1021/acsomega.1c00027

26- Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5′ NT) inhibition activities
Authors: Hafiza Amna Younus, Abdul Hameed, Abid Mahmood, Muhammad Siraj Khan, Muhammad Saeed, Farwa Batool, Asnuzilawati Asari, Habsah Mohamad, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Mariya Al‑Rashida
Bioorganic Chemistry, July 1, 2020
DOI: 10.1016/j.bioorg.2020.103827

27- The South Asian Health Foundation (UK) guidelines for managing diabetes during Ramadan
Authors: W Hanif, V Patel, SN Ali, A Karamat, M Saeed, M Hassanein, A Syed, TA Chowdhury, A Farooqi, K Khunti
Diabetes Research and Clinical Practice, June 1, 2020
DOI: 10.1016/j.diabres.2020.108145

28- Synthesis and evaluation of novel S‑benzyl‑ and S‑alkylphthalimide‑oxadiazole‑benzenesulfonamide hybrids as inhibitors of dengue virus protease
Authors: Syeda Shamila Hamdani, Bilal Ahmad Khan, Shahid Hameed, Farwa Batool, Hafiza Nosheen Saleem, Ehsan Ullah Mughal, Muhammad Saeed
Bioorganic Chemistry, March 1, 2020
DOI: 10.1016/j.bioorg.2020.103567

29- The Antidiabetic Effect of Cinnanomum zeylenicum (Girfa) Aqueous Extract on Induced Diabetic Albino Rats
Authors: MH Saeed, SMA Bakhit, LE Taha
Diabetes, 2020


30 Treatment of HCV Genotype‑1a Infection with Sofosbuvir/Daclatasvir in a Child Suffering from Thalassemia‑Major
Authors: Hafiz Javed Mansoor, Muhammad Salman Walayt, Hammad Ahmed, Mahtab Ahmad Khan, Muhammad Saeed
RADS Journal of Pharmacy and Pharmaceutical Sciences, 2020
Publications – 2019

31- Symplasmic phloem unloading and radial post‑phloem transport via vascular rays in tuberous roots of Manihot esculenta
Rabih Mehdi, Christian E Lamm, Ravi Bodampalli Anjanappa, Christina Müdsam, Muhammad Saeed, Janine Klima, Max E Kraner, Frank Ludewig, Michael Knoblauch, Wilhelm Gruissem, Uwe Sonnewald, Wolfgang Zierer
Journal of Experimental Botany, October 15, 2019
DOI: 10.1093/jxb/erz297

32- Kerr Nonlinearity in germanium selenide nanoflakes measured by Z‑scan and spatial self‑phase modulation techniques and its applications in all‑optical information conversion
Yue Jia, Zhongfu Li, Muhammad Saeed, Jie Tang, Houzhi Cai, Yuanjiang Xiang
Optics Express, July 11, 2019
DOI: 10.1364/OE.27.020857

33-Inhibition of Dengue virus protease by chemical constituents of a clove: From food ingredient to medicine
Muhammad Saeed
Conference Abstracts, American Chemical Society, March 31, 2019
DOI: 10.1021/acsomega.8b02861

34- Inhibition of Dengue Virus Protease by Eugeniin, Isobiflorin, and Biflorin Isolated from the Flower Buds of Syzygium aromaticum (Cloves)
Hafiza Nosheen Saleem, Farwa Batool, Hafiz Javed Mansoor, Syed Shahzad‑ul‑Hussan, Muhammad Saeed
ACS Omega, January 17, 2019Publications – 2018

35- A brief review on plant growth promoting rhizobacteria (PGPR): a key role in plant growth promotion
Umair Mehmood, Muhammad Inam‑ul‑Haq, Muhammad Saeed, Adeela Altaf, Farooq Azam, Sikandar Hayat
Plant Protection, September 11, 201836
DOI: 10.3389/fpls.2018.01473


36- Potential targets for therapeutic intervention and structure‑based vaccine design against Zika virus
Amina Qadir, Muhammad Riaz, Muhammad Saeed, Syed Shahzad‑ul‑Hussan
European Journal of Medicinal Chemistry, August 5, 2018
DOI: 10.1016/j.ejmech.2018.07.014

37- High rates of non‑adherence to antidiabetic, antihypertensive and lipid‑lowering treatment in patients with Type 2 diabetes revealed by LC‑MS/MS
Ali Abdulnabi Suwaidan, P Gupta, P Patel, A Burns, M Saeed, D Lane, S Seidu, K Khunti
European Heart Journal, August 1, 2018
DOI: 10.1093/eurheartj/ehy566.P6187

38- Superstructure manipulation and electronic measurement of monolayers comprising discotic liquid crystals with intrinsic dipole moment using STM/STS
Kum‑Yi Cheng, Chih‑Hsun Lin, Mei‑Chun Tzeng, Ayyaz Mahmood, Muhammad Saeed, Chun‑hsien Chen, Chi Wi Ong, Shern‑Long Lee
Chemical Communications, 2018
DOI: 10.1039/C8CC04241A

39- A preliminary list of hover flies (Diptera: Syrphidae) with new locality records from Swat, Khyber Pakhtunkhwa, Northern Pakistan
M Saeed, MA Hassan, I Mastoi, A Arshad
Journal of Entomology and Zoology Studies, 2018Publications – 2017

40- Species diversity and ethnobotanical study of Allai valley in the western Himalayan region of Pakistan
Muhammad Abbas Khan, Shah Masaud Khan, Shujaul Mulk Khan, Ijaz Hussain, Sher Aslam Khan, Muhammad Liaqat, Muhammad Saeed, Sardar Ali
Pakistan Journal of Weed Science Research, June 1, 2017
DOI: 10.28941/pjwsr.v23i2.207-220

41- Deciphering the Resistance Profile of Cancerous Thymidylate Synthase
Zahidul Islam, Ilya Gurevic, Muhammad Saeed, Sobia Rasool, Amnon Kohen
FASEB Journal, April 2017
DOI: 10.1096/fj.201601234R

42- Synthesis of lignin model compound containing a β‑O‑4 linkage
Asma Mukhtar, Muhammad Zaheer, Muhammad Saeed, Wolfgang Voelter
Zeitschrift für Naturforschung B, February 1, 2017Publications – 2015
DOI: 10.1515/znb-2016-0201

43- Resveratrol Prevents Estrogen‑DNA Adduct Formation and Neoplastic Transformation in MCF‑10F Cells
Muhammad Saeed
Cancer Prevention Research, September 18, 2015
DOI: 10.1158/1940-6207.CAPR-08-0037

44- Targeting the de Novo Biosynthesis of Thymidylate for the Development of a PET Probe for Pancreatic Cancer Imaging
Thushani D Nilaweera, Muhammad Saeed, Amnon Kohen
Biochemistry, February 10, 2015Publications – 2012
DOI: 10.1021/bi501481n

45- A fast chemoenzymatic synthesis of [11C]‑N5,N10‑methylenetetrahydrofolate as a potential PET tracer for proliferating cells
Muhammad Saeed, Timothy J Tewson, Colbin E Erdahl, Amnon Kohen
Nuclear Medicine and Biology, July 15, 2012
DOI: 10.1016/j.nucmedbio.2011.12.003

46- Effect of tumour necrosis factor‑alpha on estrogen metabolic pathways in breast cancer cells
Marwa Kamel, Samia Shouman, Mahmoud El‑Merzebany, Gokhan Kilic, Timothy Veenstra, Muhammad Saeed, Mohamed Wagih, Concepcion Diaz‑Arrastia, Deepa Patel, Salama Salama
Journal of Cancer, July 6, 2012
DOI: 10.7150/jca.4584

47- Mechanism of DNA depurination by carcinogens in relation to cancer initiation
Ercole Cavalieri, Muhammad Saeed, Muhammad Zahid, David Cassada, Daniel Snow, Momcilo Miljkovic, Eleanor Rogan
IUBMB Life, February 2012Publications – 2011
DOI: 10.1002/iub.586

48- Formation of dopamine quinone‑DNA adducts and their potential role in the etiology of Parkinson’s disease
Muhammad Zahid, Muhammad Saeed, Li Yang, Cheryl Beseler, Eleanor Rogan, Ercole L Cavalieri
IUBMB Life, December 2011
DOI: 10.1002/iub.538

49- Formation of diethylstilbestrol–DNA adducts in human breast epithelial cells and inhibition by resveratrol
Benjamin Hinrichs, Muhammad Zahid, Muhammad Saeed, Mohammed F Ali, Ercole L Cavalieri, Eleanor G Rogan
Journal of Steroid Biochemistry and Molecular Biology, November 1, 2011
DOI: 10.1016/j.jsbmb.2011.08.009

50-Novel positron emission tomography tracer distinguishes normal from cancerous cells
Muhammad Saeed, David Sheff, Amnon Kohen
Journal of Biological Chemistry, September 30, 2011
DOI: 10.1074/jbc.M111.275446

51-The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk
Marian Y Williams‑Brown, Sana M Salih, Xia Xu, Timothy D Veenstra, Muhammad Saeed, Shaleen K Theiler, Concepcion R Diaz‑Arrastia, Salama A Salama
Journal of Steroid Biochemistry and Molecular Biology, September 1, 2011Publications – 2010
DOI: 10.1016/j.jsbmb.2011.05.001


52-N‑acetylcysteine blocks formation of cancer‑initiating estrogen–DNA adducts in cells
Muhammad Zahid, Muhammad Saeed, Mohammed F Ali, Eleanor G Rogan, Ercole L Cavalieri
Free Radical Biology and Medicine, March 2010
DOI: 10.1016/j.freeradbiomed.2010.04.028

53-Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease
Muhammad Zahid, Muhammad Saeed, Eleanor G Rogan, Ercole L Cavalieri
Free Radical Biology and Medicine, February 2010
DOI: 10.1016/j.freeradbiomed.2009.11.002

Published Papers
Active Research Projects
Collaborators
%
Student Engagement
%

what we do

The Bioorganic & Medicinal Chemistry (BMC) group focuses on advancing research in organic synthesis, medicinal chemistry, and drug discovery. Our work spans from designing new molecules and polymers to interpreting NMR spectra and exploring innovative approaches in chemical education. We combine laboratory research with computational tools and science communication to train the next generation of chemists and contribute to solving real‑world challenges.

Research Expertise

Advancing synthetic organic chemistry, medicinal chemistry, and drug discovery.

Student Training

Guiding undergrad and graduate students in synthesis, computational design, and lab skills

Collaborations

Working with academia and industry to develop smart therapeutic solutions.

Publications & Outreach

Sharing discoveries through journals, conferences, and science communication.

Welcome to the Bioorganic & Medicinal Chemistry (BMC) Group

The BMC group is dedicated to advancing science at the interface of chemistry and biology. We design and synthesize novel organic molecules, apply computational chemistry and molecular modeling, and evaluate biological activity to discover new therapeutic agents and smart drug delivery platforms. Our mission is to bridge fundamental chemistry with translational biomedical research, creating solutions for cancer, viral diseases, and beyond.

Our research spans anticancer and antiviral drug discovery, endocrine‑resistant breast cancer, peptide‑based nanomaterials, stimuli‑responsive drug delivery systems, and sustainable catalytic technologies. By aligning creativity with rigorous science, we aim to transform challenges into opportunities for innovation. We believe that the future of medicine lies in interdisciplinary collaboration, and we are committed to training the next generation of scientists to lead this transformation.

“Where molecules meet medicine, innovation begins.” – BMC Group Vision

We envision a world where chemistry empowers health, discovery fuels progress, and collaboration drives breakthroughs.