{"id":55,"date":"2026-07-14T20:40:26","date_gmt":"2026-07-14T20:40:26","guid":{"rendered":"https:\/\/medchem.lums.edu.pk\/index.php\/penny-grow-about-us\/"},"modified":"2026-08-26T22:18:36","modified_gmt":"2026-08-26T22:18:36","slug":"penny-grow-about-us","status":"publish","type":"page","link":"https:\/\/medchem.lums.edu.pk\/?page_id=55","title":{"rendered":"Penny Grow About us"},"content":{"rendered":"\t\t
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Publications<\/strong>

 2026<\/strong>

<\/em>Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 3-(benzo[d][1,3]dioxol-5-yl)-2-(pyridin-3-yl) thiazolidin-4-one.<\/strong>
Authors: Summara Kousar, Raed Al\u2011Qawasmeh, Monther Khanfar, Muhammad Saeed
Journal: European Journal of Chemistry<\/em> 17(2), 99\u2013108
Publication Date: June 30, 2026
DOI<\/strong>: https:\/\/doi.org\/10.5155\/eurjchem.17.2.99-108.2778<\/em><\/a>

Selective Plastic Photo Upcycling to Acetic Acid via Coupled Oxidation and CO\u2082 Reduction Over an S\u2011Scheme g\u2011C\u2083N\u2084\/Fe\u2082O\u2083 Heterojunction<\/strong>
Authors: Zunaira Muhammad, Muhammad Saeed, Senem \u00c7ito\u011flu, Hatice Duran, Salman Noshear Arshad
Journal: ChemPlusChem<\/em> 91(4), e202500710
First Published: April 16, 2026
DOI<\/strong>: https:\/\/doi.org\/10.1002\/cplu.202500710<\/a>

  2025<\/strong>

Thermoselective Synthesis of Drug Intermediates Using Sulphonic Acid Functionalized Heterogeneous Catalysts<\/strong>
Authors: Shahzad Rasheed, Summara Kousar, Muhammad Saeed, Qandeel Almas
Conference: 2025 AIChE Annual Meeting<\/em>
Publisher: AIChE
Publication Date: November 4, 2025

Probing Solid\u2011Supported Alkali and Alkaline Earth Metal Salts\u2011Based Catalysts in the Multicomponent Synthesis of Acridine\u20111,8\u2011diones: Box\u2013Behnken and Density Functional Theory (DFT) Study<\/strong>
Authors: Nisar Ali, Sehrish Sarfaraz, Hina Asif, Minahil Abbas, Mariya Al\u2011Rashida, Muhammad Saeed, Sobia Rana, Khurshid Ayub, Abdul Hameed
Journal: ChemistrySelect<\/em> 10(37), e04095
DOI<\/strong>: https:\/\/doi.org\/10.1002\/slct.202504095<\/a>

Synthesis, mechanistic insights, and anticancer evaluation of novel 2\u2011aroylbenzo[b]thiophen\u20113\u2011ols: A DFT and Hirshfeld surface analysis<\/strong>
Authors: Asma Mukhtar, Ali Iftikhar, Maria Maqbool, Amir Faisal, Khurshid Ayub, Sammer Yousuf, Muhammad Saeed
Journal: Journal of Molecular Structure<\/em> 1324, 140802
DOI:<\/strong> https:\/\/doi.org\/10.1016\/j.molstruc.2024.140802

 2024<\/strong>


Fabrication of CuWO\u2084@MIL\u2011101 (Fe) nanocomposite for efficient OER and photodegradation of methylene blue<\/strong>
Authors: Mariam Khan, M.M. Ahmed, M.N. Akhtar, M. Sajid, N.N. Riaz, M. Asif, M. Kashif, \u2026 Muhammad Saeed
Journal: Heliyon<\/em> 10(23)
Publication Year: 2024
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.heliyon.2024.e40546<\/a>

Optimization study and application of Box\u2013Behnken model for probing eggshell supported transition metals based catalysts to synthesize hydrazone & dihydropyrimidinones<\/strong>
Authors: Rabia Perveen, F. Latif, M. Abbas, K. Ayub, S. Sarfaraz, Muhammad Saeed, S. Rana, \u2026
Journal: Scientific Reports<\/em> 14(1), 23270
DOI<\/strong>: https:\/\/doi.org\/10.1038\/s41598-024-74876-6<\/a>

Synthesis of 3\u2011methyl\u2011N\u2011((4\u2032-(3\u2011methylbenzamido)\u2011[1,1\u2032\u2011biphenyl]\u20114\u2011yl) carbamothioyl) benzamide: X\u2011ray structural analysis, DFT\u2011guided investigation, Hirshfeld analysis<\/strong>
Authors: Faiza Younas, A. Saeed, T. H\u00f6kelek, C. Schulzke, S. Tahira, B.J. Elvers, Muhammad Saeed
Journal: Journal of Molecular Structure<\/em> 1311, 138399
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.molstruc.2024.138399

Iron\u2011catalysed C\u2013H ortho\u2011arylation of edaravone, a promising monoamine oxidase\u2011B inhibitor<\/strong>
Authors: Soneela Asghar, Mattia Manzotti, Alexander Atkins, S. Tailor, H.A. Sparkes, Muhammad Saeed, \u2026
Journal: Tetrahedron<\/em> 158, 133983
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.tet.2024.133983<\/a>

Facile synthesis of substituted 2\u2011aroylbenzo[b]thiophen\u20113\u2011ols to form novel triazole hybrids using click chemistry<\/strong>
Authors: Asma Mukhtar, Arif Hussain, Faiza Younas, Sammer Yousuf, Muhammad Saeed
Journal: RSC Advances<\/em> 14(15), 10270\u201310279
DOI: https:\/\/doi.org\/10.1039\/d4ra01146e<\/a>


2023<\/strong>

Part\u2011II: An update of Schiff bases synthesis and applications in medicinal chemistry \u2013 a patent review (2016\u20132023)<\/strong>
Authors: Hafiza Amna Younus, Farwa Saleem, A. Hameed, Mariya Al\u2011Rashida, Raed Al\u2011Qawasmeh, \u2026 Muhammad Saeed
Journal: Expert Opinion on Therapeutic Patents<\/em> 33(12), 841\u2013864


Repurposing of investigational cancer drugs: Early phase discovery of dengue virus NS2B\/NS3 protease inhibitors<\/strong>
Authors: Hafiza Nosheen Saleem, Summara Kousar, A.H. Jiskani, I. Sohail, Amir Faisal, Muhammad Saeed
Journal: Archiv der Pharmazie<\/em> e2300292
DOI<\/strong>:https:\/\/doi.org\/10.1002\/ardp.20230029<\/a>
2<\/a>

The photocatalytic and antibacterial potential of highly efficient S\u2011scheme binary S\u2011gC\u2083N\u2084@Co\u2011zinc ferrite nanocomposite<\/strong>
Authors: Syeda Saba Hassan, M. Javed, M.N. Akhtar, M.A. Qamar, N. Ahmed, Muhammad Saeed, \u2026
Journal: Optical Materials<\/em> 142, 114046
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.optmat.2023.114046<\/a>

Plasma\u2011based ozonolysis of lignin waste materials for the production of value\u2011added chemicals<\/strong>
Authors: Rabia Muazzam, A. Hafeez, M. Uroos, Muhammad Saeed, F. Rehman, N. Muhammad
Journal: Biomass Conversion and Biorefinery<\/em> 13, 5903\u20135919
DOI:<\/strong> https:\/\/doi.org\/10.1007\/s13399-021-01707-3<\/a>

Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: synthesis, biological evaluation and in silico study<\/strong>
Authors: Hafiza Amna Younus, Muhammad Saeed, A. Mahmood, M.S.K. Jadoon, A. Hameed, A. Asari, \u2026
Journal: Bioorganic Chemistry<\/em> 134, 106450
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.bioorg.2023.106450<\/a>


2022<\/strong>

Endophytic bacteria of Fagonia indica<\/em> Burm. f revealed to harbour rich secondary antibacterial metabolites<\/strong>
Authors: Lubna Rahman, Asma Mukhtar, S. Ahmad, L. Rahman, M. Ali, Muhammad Saeed, Z.K. Shinwari
Journal: PLOS ONE<\/em> 17(12), e0277825
DOI<\/strong>:https:\/\/doi.org\/10.1371\/journal.pone.0277825

Synthesis, X\u2011Ray crystallography and HF\/DFT analysis of N\u2011(diethylcarbamothioyl) furan\u20112\u2011carboxamide, analyzed by experimental and theoretical methods<\/strong>
Authors: A. Saeed, S. Ashraf, G. Shabir, T. H\u00f6kelek, U. Fl\u00f6rke, Asma Mukhtar, Muhammad Saeed
Journal: Journal of Molecular Structure<\/em> 1268, 133721
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.molstruc.2022.133721

Novel carboxylic acid\u2011capped silver nanoparticles as antimicrobial and colorimetric sensing agents<\/strong>
Authors: Muhammad Imran Irfan, F. Amjad, A. Abbas, M.F.U. Rehman, F. Kanwal, Muhammad Saeed, S. Ullah, \u2026
Journal: Molecules<\/em> 27(11), 3363
DOI<\/strong>:https:\/\/doi.org\/10.3390\/molecules27113363<\/a>

Synthetic flavonoids as potential antiviral agents against SARS\u2011CoV\u20112 main protease<\/strong>
Authors: Farwa Batool, Ehsan Ullah Mughal, K. Zia, A. Sadiq, N. Naeem, A. Javid, Z. Ul\u2011Haq, \u2026 Muhammad Saeed
Journal: Journal of Biomolecular Structure and Dynamics<\/em> 40(8), 3777\u20133788
DOI:https:\/\/doi.org\/10.1080\/07391102.2022.2045678<\/a>

Postharvest shelf life enhancement of peach fruit treated with glucose oxidase immobilized on ZnO nanoparticles<\/strong>
Authors: Razia Batool, S.A.R. Kazmi, S. Khurshid, Muhammad Saeed, S. Ali, A. Adnan, F. Altaf, \u2026
Journal: Food Chemistry<\/em> 366, 130591
DOI:https:\/\/doi.org\/10.1016\/j.foodchem.2021.130591

2021<\/strong>

Minocycline Derived Silver Nanoparticles for Assessment of Their Antidiabetic Potential against Alloxan induced Diabetic Mice<\/strong>
Authors: Syed Akif Raza Kazmi, M.Z. Qureshi, S.S. Alhewairini, S. Ali, S. Khurshid, Muhammad Saeed, \u2026
Journal: Pharmaceutics<\/em> 13(10), 1678
DOI:https:\/\/doi.org\/10.3390\/pharmaceutics13101678<\/a>

Catalytic C\u2013O bond cleavage in a \u03b2\u2011O\u20114 lignin model through intermolecular hydrogen transfer<\/strong>
Authors: Muhammad Ahsan Usman, M. Naeem, Muhammad Saeed, M. Zaheer
Journal: Inorganica Chimica Acta<\/em> 521, 120305
DOI:https:\/\/doi.org\/10.1016\/j.ica.2021.120305<\/a>

Facile Synthesis and In Vitro Activity of N\u2011Substituted 1,2\u2011Benzisothiazol\u20113(2H)\u2011ones against Dengue Virus NS2BNS3 Protease<\/strong>
Authors: Farwa Batool, Muhammad Saeed, Hafiza Nosheen Saleem, L. Kirschner, J. Bodem
Journal: Pathogens<\/em> 10(4), 464
DOI:https:\/\/doi.org\/10.3390\/pathogens10040464<\/a>

Schiff\u2011based metal complexes of lamotrigine: design, synthesis, characterization, and biological evaluation<\/strong>
Authors: Saima Najm, Humaira Naureen, K. Sultana, F. Anwar, M.M. Khan, H. Nadeem, Muhammad Saeed
Journal: ACS Omega<\/em> 6(11), 7719
DOI:https:\/\/doi.org\/10.1021\/acsomega.1c00027<\/a>
         
2020<\/strong>

Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5\u2032 NT) inhibition activities<\/strong>
Authors: Hafiza Amna Younus, A. Hameed, A. Mahmood, M.S. Khan, Muhammad Saeed, Farwa Batool, \u2026
Journal: Bioorganic Chemistry<\/em> 100, 103827
DOI:https:\/\/doi.org\/10.1016\/j.bioorg.2020.103827

Synthesis and evaluation of novel S\u2011benzyl\u2011 and S\u2011alkylphthalimide\u2011oxadiazole\u2011benzenesulfonamide hybrids as inhibitors of dengue virus protease<\/strong>
Authors: Syeda Shamila Hamdani, B.A. Khan, S. Hameed, Farwa Batool, Hafiza Nosheen Saleem, E.U. Mughal, \u2026 Muhammad Saeed
Journal: Bioorganic Chemistry<\/em> 96, 103567
DOI:https:\/\/doi.org\/10.1016\/j.bioorg.2020.103567<\/a>

Treatment of HCV Genotype\u20111a Infection with Sofosbuvir\/Daclatasvir in a Child Suffering from Thalassemia\u2011Major<\/strong>
Authors: Hafiz Javed Mansoor, M.S. Walayt, H. Ahmed, M.A. Khan, Muhammad Saeed
Journal: RADS Journal of Pharmacy and Pharmaceutical Sciences<\/em> 8(3), 168\u2013172

 2019<\/strong>

Inhibition of Dengue Virus Protease by Eugeniin, Isobiflorin, and Biflorin Isolated from the Flower Buds of Syzygium aromaticum<\/em> (Cloves)<\/strong>
Authors: Hafiza Nosheen Saleem, Farwa Batool, Hafiz Javed Mansoor, S. Shahzad\u2011ul\u2011Hussan, Muhammad Saeed
Journal: ACS Omega<\/em> 4(1), 1525\u20131533
DOI:https:\/\/doi.org\/10.1021\/acsomega.8b02861<\/a>

Kerr Nonlinearity in germanium selenide nanoflakes measured by Z\u2011scan and spatial self\u2011phase modulation techniques<\/strong>
Authors: Yue Jia, Muhammad Saeed, \u2026
Journal: Optics Express<\/em> 27, 20857
DOI:<\/strong> https:\/\/doi.org\/10.1364\/OE.27.020857<\/a>

2018<\/strong>

Potential targets for therapeutic intervention and structure\u2011based vaccine design against Zika virus<\/strong>
Authors: Amina Qadir, M. Riaz, Muhammad Saeed, S. Shahzad\u2011ul\u2011Hussan
Journal: European Journal of Medicinal Chemistry<\/em> 156, 444\u2013460
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.ejmech.2018.07.014<\/a>
                        
 2017<\/strong>

Deciphering the Resistance Profile of Cancerous Thymidylate Synthase<\/strong>
Authors: Z. Islam, I. Gurevic, Muhammad Saeed, S. Rasool, Amnon Kohen
Journal: FASEB Journal<\/em> 31, 921.12


Synthesis of lignin model compound containing a \u03b2\u2011O\u20114 linkage<\/strong>
Authors: Asma Mukhtar, M. Zaheer, Muhammad Saeed, W. Voelter
Journal: Zeitschrift f\u00fcr Naturforschung B<\/em> 72(2), 119\u2013124
DOI<\/strong>: https:\/\/doi.org\/10.1515\/znb-2016-0201<\/a>  

 2015<\/strong>


Targeting the de novo Biosynthesis of Thymidylate for PET Probe Development in Pancreatic Cancer Imaging<\/strong>
Authors: Thushani D. Nilaweera, Muhammad Saeed, Amnon Kohen
Journal: Biochemistry<\/em> 54(5), 1287\u20131295
Year: 2015
DOI: https:\/\/doi.org\/10.1021\/bi501481n<\/a>

2012<\/strong>

A fast chemoenzymatic synthesis of [\u00b9\u00b9C]\u2011N\u2075,N\u00b9\u2070\u2011methylenetetrahydrofolate as a potential PET tracer for proliferating cells<\/strong> Authors: Muhammad Saeed, Timothy J. Tewson, Colbin E. Erdahl, Amnon Kohen Journal: Nuclear Medicine and Biology<\/em> 39(5), 697\u2013701
Publication Date: July 15, 2012
DOI<\/strong>:https:\/\/doi.org\/10.1016\/j.nucmedbio.2011.12.003<\/a>

A fast chemoenzymatic synthesis of [11C]\u2011N5,N10\u2011methylenetetrahydrofolate as a potential PET tracer for proliferating cells<\/strong>
Authors: Muhammad Saeed, T.J. Tewson, C.E. Erdahl, Amnon Kohen
Journal: Nuclear Medicine and Biology<\/em> 39(5), 697\u2013701
DOI:https:\/\/doi.org\/10.1016\/j.nucmedbio.2011.12.003<\/a>

Effect of tumour necrosis factor\u2011alpha on estrogen metabolic pathways in breast cancer cells<\/strong>
Authors: M. Kamel, S. Shouman, M. El\u2011Merzebany, G. Kilic, T. Veenstra, Muhammad Saeed, \u2026
Journal: Journal of Cancer<\/em> 3, 310\u2013319


Mechanism of DNA depurination by carcinogens in relation to cancer initiation<\/strong>
Authors: Ercole Cavalieri, Muhammad Saeed, M. Zahid, D. Cassada, D. Snow, M. Miljkovic, \u2026
Journal: IUBMB Life<\/em> 64(2), 169\u2013179
DOI: https:\/\/doi.org\/10.1002\/iub.58<\/a>

 2011<\/strong>

Formation of dopamine quinone\u2011DNA adducts and their potential role in the etiology of Parkinson\u2019s disease<\/strong>
Authors: M. Zahid, Muhammad Saeed, L. Yang, C. Beseler, E. Rogan, E.L. Cavalieri
Journal: IUBMB Life<\/em> 63(12), 1087\u20131093
DOI: https:\/\/doi.org\/10.1002\/iub.538<\/a>

Formation of diethylstilbestrol\u2013DNA adducts in human breast epithelial cells and inhibition by resveratrol<\/strong>
Authors: B. Hinrichs, M. Zahid, Muhammad Saeed, M.F. Ali, E.L. Cavalieri, E.G. Rogan
Journal: Journal of Steroid Biochemistry and Molecular Biology<\/em> 127(3\u20135), 276\u2013281
DOI: https:\/\/doi.org\/10.1016\/j.jsbmb.2011.03.012 (doi.org in Bing)<\/a>

Novel positron emission tomography tracer distinguishes normal from cancerous cells<\/strong>
Authors: Muhammad Saeed, D. Sheff, Amnon Kohen
Journal: Journal of Biological Chemistry<\/em> 286(39), 33872\u201333878
DOI: https:\/\/doi.org\/10.1074\/jbc.M111.275446<\/a>

The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk<\/strong>
Authors: M.Y. Williams\u2011Brown, S.M. Salih, X. Xu, T.D. Veenstra, Muhammad Saeed, S.K. Theiler, \u2026
Journal: Journal of Steroid Biochemistry and Molecular Biology<\/em> 126(3\u20135), 78\u201386
DOI:https:\/\/doi.org\/10.1016\/j.jsbmb.2011.03.010

Resveratrol and N\u2011acetylcysteine block the cancer\u2011initiating step in MCF\u201110F cells<\/strong>
Authors: M. Zahid, Muhammad Saeed, C. Beseler, E.G. Rogan, E.L. Cavalieri
Journal: Free Radical Biology and Medicine<\/em> 50(1), 78\u201385
DOI: https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.10.701


                          




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The Bioorganic & Medicinal Chemistry (BMC) group focuses on advancing research in organic synthesis, medicinal chemistry, and drug discovery. Our work spans from designing new molecules and polymers to interpreting NMR spectra and exploring innovative approaches in chemical education. We combine laboratory research with computational tools and science communication to train the next generation of chemists and contribute to solving real\u2011world challenges.<\/p>\t\t\t\t<\/div>\n\t\t\t\t

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Research Expertise <\/h2> <\/div>\n

Advancing synthetic organic chemistry, medicinal chemistry, and drug discovery.<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Student Training<\/h2> <\/div>\n

Guiding undergrad and graduate students in synthesis, computational design, and lab skills<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Collaborations <\/h2> <\/div>\n

Working with academia and industry to develop smart therapeutic solutions.<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Publications & Outreach <\/h2> <\/div>\n

Sharing discoveries through journals, conferences, and science communication.<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Publications  2026 Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 3-(benzo[d][1,3]dioxol-5-yl)-2-(pyridin-3-yl) thiazolidin-4-one. Authors: Summara Kousar, Raed Al\u2011Qawasmeh, Monther Khanfar, Muhammad SaeedJournal: European Journal of Chemistry 17(2), 99\u2013108Publication Date: June 30, 2026DOI: https:\/\/doi.org\/10.5155\/eurjchem.17.2.99-108.2778 Selective Plastic Photo Upcycling to Acetic Acid via Coupled Oxidation and CO\u2082 Reduction Over an S\u2011Scheme g\u2011C\u2083N\u2084\/Fe\u2082O\u2083 Heterojunction Authors: Zunaira Muhammad, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-55","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=\/wp\/v2\/pages\/55","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55"}],"version-history":[{"count":231,"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=\/wp\/v2\/pages\/55\/revisions"}],"predecessor-version":[{"id":1147,"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=\/wp\/v2\/pages\/55\/revisions\/1147"}],"wp:attachment":[{"href":"https:\/\/medchem.lums.edu.pk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}